Misuse of Inhaled Bronchodilator Agents

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Misuse of Inhaled Bronchodilator Agents.

In the course of doing simple lung-function tests on patients with chronic bronchitis, asthma, or emphysema it became clear that many of those using bronchodilator aerosols were not using them correctly. Since it seemed possible that such patients might not be gaining maximum benefit, and since the recently developed pressurized aerosols are expensive, it was thought reasonable to examine in mo...

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Inhaled bronchodilators are routinely administered to mechanically ventilated patients to relieve dyspnea and reverse bronchoconstriction. A lower percentage of the nominal dose reaches the lower respiratory tract in a mechanically ventilated patient than in a nonintubated subject, but attention to device selection, administration technique, dosing, and patient-ventilator interface can increase...

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The effects of inhaling nitric oxide (NO) on airway mechanics were studied in anesthetized and mechanically ventilated guinea pigs. In animals without induced bronchoconstriction, breathing 300 ppm NO decreased baseline pulmonary resistance (RL) from 0.138 +/- 0.004 (mean +/- SE) to 0.125 +/- 0.002 cmH2O/ml.s (P less than 0.05). When an intravenous infusion of methacholine (3.5-12 micrograms/kg...

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ژورنال

عنوان ژورنال: BMJ

سال: 1965

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.5441.1037